Bing Gan

A Multi-Disciplinary Framework for Decoding S1PR1-Selective Agonism

The paper reports cryo-EM structures of S1PR1-Gi complexes bound to agonists and identifies molecular features driving selectivity for S1PR1 over S1PR3 and S1PR5.

Crystal structure of the MBD domain of MBD3 in complex with methylated CG DNA

This study determines the crystal structure of the MBD3 MBD domain bound to methylated CG DNA, revealing its binding mechanism and preference for mCG over hmCG.