Jinrong Min

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

This study identifies H3K14ac as a maternal factor that recruits Eggless/SetDB1 to establish constitutive heterochromatin during early Drosophila embryogenesis.

This study shows PHF1 and PHF19 Tudor domains preferentially bind H3tK27me3 over canonical H3K27me3, revealing structural basis for their recognition.

This study determines the structural basis for CDY chromodomain selectivity in binding lysine-methylated ARKS motifs, revealing distinct preferences for H3K9me3 and H3K27me3.

The paper investigates how acetylation and phosphorylation of RNA polymerase II CTD interact through RPRD proteins, showing acetylation regulates phosphorylation and vice versa.

This study determines the crystal structure of the MBD3 MBD domain bound to methylated CG DNA, revealing its binding mechanism and preference for mCG over hmCG.