Bingbing Yu

Aminoacylated tRNA tails trigger auxiliary bacterial immunity

The paper shows that cleaved aminoacylated tRNA tails trigger auxiliary bacterial immunity by activating Adt1, leading to mRNA cleavage and cellular dormancy.

Cleavage of the catalytic intermediate fine-tunes cGAS signalling

The paper identifies a regulatory mechanism that tunes cGAS signaling by cleaving a catalytic intermediate, preventing excessive activation while preserving immune function.

DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants

This study identifies DNA-terminus-initiated transcription by T7 RNA polymerase as the main source of dsRNA byproducts and shows that a C-helix mutant reduces dsRNA production and improves mRNA quality.

A single mutation attenuates both the transcription termination and RNA-dependent RNA polymerase activity of T7 RNA polymerase

The paper identifies a single mutation, S43Y, that reduces transcription termination and RNA-dependent RNA polymerase activity in T7 RNA polymerase.

In vitro transcription using psychrophilic phage VSW-3 RNA polymerase

This paper characterizes a psychrophilic phage RNA polymerase that improves RNA purity and stability in vitro transcription by reducing dsRNA by-products and RNA degradation.