Jack P. K. Bravo

The paper shows that cleaved aminoacylated tRNA tails trigger auxiliary bacterial immunity by activating Adt1, leading to mRNA cleavage and cellular dormancy.

This study identifies Tiamat as an ATPase and DNase in bacteria and shows its homologs are widespread across eukaryotes, with some acquiring non-defense roles.

This study reports cryo-EM structures of Cas9d, revealing its DNA targeting mechanism and demonstrating a compact variant with robust nuclease activity in mammalian cells.

This study investigates how SpRY-Cas9 recognizes DNA targets without requiring a PAM sequence, revealing structural and kinetic mechanisms that improve genome editing versatility.

The paper shows that a single 2'-O-methylation of ribosomal RNA is essential for ribosome assembly and nuclear export, with Nog2 interacting specifically with the methylated base.