Yan Yan

Aminoacylated tRNA tails trigger auxiliary bacterial immunity

The paper shows that cleaved aminoacylated tRNA tails trigger auxiliary bacterial immunity by activating Adt1, leading to mRNA cleavage and cellular dormancy.

Ref(2)P/p62 protein pleomorphism confers tissue-specific function

One Drosophila Ref(2)P polypeptide takes different structures in midgut and muscle, driving autophagy or mitochondria-associated degradation; deleting disordered region IDR2 switches muscle Ref(2)P to midgut state.

PI-FC: Pre-training Individual-specific Functional Connectome through State-invariant Contrastive Learning

PI-FC uses state-invariant contrastive learning to extract stable individual brain signatures from fMRI, improving phenotypic prediction accuracy and reducing scanning time across multiple datasets.

Epigenetic reprogramming induced by Acetyl-CoA and SAM depletion is an evolutionarily-ancient path to malignant growth

This study identifies common metabolic and epigenetic changes in fly and human tumors, showing that metabolite depletion drives tumorigenesis across species.

Longevity or Well-being? A Dual-Dimension Structure of Neuroticism

The paper proposes that neuroticism variability can be structured into two dimensions, one linked to longevity and the other to well-being, with distinct neural and genetic underpinnings.

More Severe Loss-of-Function Sodium Channel induced by Compound SCN5A R965C and R1309H Mutants lead to Complex Familial Arrhythmia Syndrome.

The paper identifies a compound SCN5A mutation R965C-R1309H in a family with arrhythmia syndrome, showing it causes more severe sodium channel dysfunction than either mutation alone.