Author

Bo Zeng

University of Electronic Science and Technology of China

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Ce WangiD· 1 shared Changhu Xue· 1 shared David E. Clapham· 1 shared Gui-Lan Chen· 1 shared Guoling HuangiD· 1 shared Heping Wang· 1 shared Jian LiiD· 1 shared Jianbin Wang· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Ce WangORCID

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2 papers

Recent·Most cited

Myeloid DC-SIGN drives tumor immune evasion and resistance to PD-1 blockade through ICAM-2-ERM-mediated T-cell mechanosuppression

Ting Pan, T Z Wang, Jiaqi Wu, Heping Wang, Bo Zeng, Yangyang Li, Ming Yi, Ruirui He, Lingyun Feng, Zhihui Cui, Guoling Huang, Panyin Shu, Xi Li, Yuan Wang, Yanyun Du, , Ce Wang

This study identifies DC-SIGN as a mechanosuppressive checkpoint that drives tumor immune evasion and resistance to PD-1 blockade by suppressing T-cell function through ICAM-2-ERM signaling.

bioRxiv · Jun 16, 2026 · PreprintImmunology

Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

Jingjing Duan, Jian Li, Gui-Lan Chen, Bo Zeng, Kechen Xie, Xiaogang Peng, Wei Zhou, Jianing Zhong, Yixing Zhang, Jie Xu, Changhu Xue, Lan Zhu, Wei Liu, Xiao-Li Tian, Jianbin Wang, , Jin Zhang

The paper presents the 2.9 angstrom cryo-EM structure of TRPC5, revealing its partially open apo state and structural differences from other TRP channels.

bioRxiv · Nov 11, 2018 · PreprintBiophysics