Wei Zhou

Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation

This paper develops in vivo compressed AAV-Perturb-seq to study gene knockouts in cardiomyocytes, finding mitochondrial transcriptome changes are a common response to genetic perturbation.

Species and strain diversity in Staphylococcus drive divergent host responses in human skin

The paper profiles skin responses to 187 Staphylococcus strains across seven species in a human skin model, revealing strain-level diversity in host immune and barrier responses.

Population genomics of skin Staphylococcus reveals disease-associated restructuring of species and strain diversity

This study sequenced 2,920 skin Staphylococcus isolates to show disease selects species-level traits while reshaping strain populations and their functional diversity within hosts.

Neuronal EphB2 signaling drives persistent neuropathic pain following spinal cord injury

This study identifies EphB2 signaling in neurons as a mechanism maintaining neuropathic pain after spinal cord injury.

DEEPReditor-CMG: A deep-learning-based predictive RNA editor for crop mitochondria genomes

The paper develops DEEPReditor-CMG, a deep learning model for predicting C-to-U RNA editing sites in crop mitochondrial genomes, showing improved accuracy and uncovering evolutionary patterns.

Impaired Functional Connectivity of Cortico-Amygdala Pathway Can Drive Social Behavior Deficits in Synucleinopathies

This study shows that -synuclein aggregation disrupts cortico-amygdala connectivity, leading to social behavior deficits in synucleinopathies, and that restoring this connection can rescue the behavior.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

The reduced prevalence of macrolide resistance in Mycoplasma pneumoniae clinical isolates from pediatric patients in Beijing in 2016

The study reports macrolide resistance rates in Mycoplasma pneumoniae isolates from pediatric patients in Beijing, 2016, and identifies specific mutations associated with resistance.