Cancer BiologybioRxivPreprint
Hypoxia-inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion
Soma Seal, Rebecca A. Luchtel, Talia Akram…·Niraj Konchady Shenoy
This study identifies hypoxia-inducible factors (HIFs) as drivers of miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer, independent of 14q deletion, revealing a feedback loop and potential therapeutic targets.
DOI 10.1101/2024.12.01.625494