BioinformaticsbioRxivPreprint
Zero-shot biological reasoning with open-weights large language models reproduces CRISPR screen based prediction of synthetic lethal interactions.
Aurél György Prósz, Zsófia M. Sztupinszki, Miklós Dióssy…·Zoltán Szállási
This paper uses open-weight large language models to predict synthetic lethal interactions, outperforming random chance and non-LLM methods in reproducing CRISPR screen results.
DOI 10.64898/2026.01.28.702211