Developmental BiologybioRxiv
Trophoblast survival signaling during human placentation requires HIF-induced transcription of HSP70
Chandni V Jain, Philip Jessmon, Charbel T Barrak…·D. Randall Armant
The paper shows that HIF-induced HSP70 transcription is essential for MMP2 accumulation and HBEGF shedding, promoting trophoblast survival under hypoxia during early human placental development.
DOI 10.1038/cdd.2017.104