Seyed Ali Biashad

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

This study shows that SIRT6 Serine 10 mutations in mice affect DNA repair, LINE1 expression, and lifespan, with reduced LINE1 control having a stronger impact on lifespan than enhanced DNA repair.

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.