Author

Brian Kosmyna

Albert Einstein College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Charles C. QueryiD· 2 shared Adam HaimowitziD· 1 shared Alyssa D. Casill· 1 shared Christopher R. TrottaiD· 1 shared Jairo Sierra· 1 shared Jingxin WangiD· 1 shared Joseph A. GiovinazzoiD· 1 shared Karoline A. LambertiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Charles C. QueryORCID

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Author profile →

3 papers

Recent·Most cited

The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function

Zhiling Kuang, Brian Kosmyna, Xueni Li, Zhichao Tang, Shasha Shi, Karoline A. Lambert, Wenzheng Zhang, Joseph A. Giovinazzo, Kerstin A. Effenberger, Jairo Sierra, Lanqing Ying, Scott J. Barraza, Wencheng Li, Jingxin Wang, Christopher R. Trotta, Rui Zhao

This study shows that U1C and Helix H of U1 snRNA are essential for branaplam's effect on weak 5 splice site recognition, while risdiplam requires additional factors for activity.

Nature Communications · Jul 16, 2026Peer-reviewedBiochemistry

Spatial organization of transcript elongation and splicing kinetics

Alyssa D. Casill, Adam Haimowitz, Brian Kosmyna, Charles C. Query, Kenny Q. Ye, Matthew J. Gamble

This study measures Pol II elongation and splicing kinetics genome-wide and finds they are coordinated by spatial genomic organization, particularly within TADs.

bioRxiv · Jan 28, 2021 · PreprintMolecular Biology

Transcriptional analysis supports the expression of human snRNA variants and reveals U2 snRNA homeostasis by an abundant U2 variant

Brian Kosmyna, Varun Gupta, Charles C. Query

The paper identifies transcribed snRNA variants and shows how sequence variation and promoter regulation affect U2 snRNA homeostasis and splicing.

bioRxiv · Jan 24, 2020 · PreprintMolecular Biology