Author

Jairo Sierra

PTC Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Brian Kosmyna· 1 shared Christopher R. TrottaiD· 1 shared Jingxin WangiD· 1 shared Joseph A. GiovinazzoiD· 1 shared Karoline A. LambertiD· 1 shared Kerstin A. Effenberger· 1 shared Lanqing Ying· 1 shared Rui ZhaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Brian Kosmyna

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1 paper

Recent·Most cited

The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function

Zhiling Kuang, Brian Kosmyna, Xueni Li, Zhichao Tang, Shasha Shi, Karoline A. Lambert, Wenzheng Zhang, Joseph A. Giovinazzo, Kerstin A. Effenberger, Jairo Sierra, Lanqing Ying, Scott J. Barraza, Wencheng Li, Jingxin Wang, Christopher R. Trotta, Rui Zhao

This study shows that U1C and Helix H of U1 snRNA are essential for branaplam's effect on weak 5 splice site recognition, while risdiplam requires additional factors for activity.

Nature Communications · Jul 16, 2026Peer-reviewedBiochemistry