Author

Zhiling Kuang

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Rui ZhaoiD· 3 shared Shasha ShiiD· 2 shared Xueni LiiD· 2 shared Zhichao TangiD· 2 shared Aaron IssaianiD· 1 shared Angelo D’AlessandroiD· 1 shared Ani SolankiiD· 1 shared Benjamin Jung FairiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

Rui ZhaoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function

Zhiling Kuang, Brian Kosmyna, Xueni Li, Zhichao Tang, Shasha Shi, Karoline A. Lambert, Wenzheng Zhang, Joseph A. Giovinazzo, Kerstin A. Effenberger, Jairo Sierra, Lanqing Ying, Scott J. Barraza, Wencheng Li, Jingxin Wang, Christopher R. Trotta, Rui Zhao

This study shows that U1C and Helix H of U1 snRNA are essential for branaplam's effect on weak 5 splice site recognition, while risdiplam requires additional factors for activity.

Nature Communications · Jul 16, 2026Peer-reviewedBiochemistry

Depleting prion protein using splice-switching small molecules

Bo Liu, Benjamin Jung Fair, Zhiling Kuang, Zhichao Tang, Junxing Zhao, Lixian Zhou, Qingyao Kong, Ani Solanki, Connor J. Kenny, James A. Mastrianni, Rui Zhao, Yang Li, Jingxin Wang

This study develops a small-molecule approach to reduce prion protein by modulating pre-mRNA splicing, achieving ~70% PrP reduction in cells and demonstrating synergistic effects with a Luc7L activator in mice.

bioRxiv · Jun 27, 2026 · PreprintBiochemistry

U1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast

Xueni Li, Jiaqin Li, Shasha Shi, Zhiling Kuang, Pankaj K. Srivastava, Aaron Issaian, Shaun G. Bevers, Marisa Elise Wagley, Angelo D’Alessandro, Rui Zhao

The paper investigates the interaction between U1 snRNP and RNA polymerase II in yeast, finding that Prp40, not U1-70K, mediates this interaction, contrasting with the human system.

Nucleic Acids Research · Jun 8, 2026Peer-reviewedBiochemistry