Cancer BiologybioRxivPreprint
Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22
Elisia Villemure, Robert L. Yauch, Joachim Rudolph…·Joyce Liu
This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.