Neuronal activity promotes repair by microglial reprogramming following demyelination
C Perrot, Rémi Ronzano, Z Li, Marie‐Stéphane Aigrot, Vasiliki Pantazou, Paul Stheneur, François‐Xavier Lejeune, Bernard Zalc, Francisco Javier Quintana, Bruno Stankoff, Catherine Lubetzki, Anne Desmazières
This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.
bioRxiv · Nov 19, 2025 · PreprintNeuroscience