Francisco Javier Quintana

This study shows that exhausted CD8 T cells can produce IFN-gamma in response to IL-12 and IL-18, indicating retained cytokine-driven effector capacity.

This study establishes an ex vivo brain slice culture platform to study glial cell responses and multicellular communication in adult human brain tissue.

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

This study shows microglia regulate cerebral blood flow through CD39-mediated ATP breakdown, affecting neurovascular coupling and CBF reactivity.

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.