Zhe Li

This study shows that RUNX1 loss in ER+ breast cancer promotes immune-active tumor formation through interferon signaling activation.

This study shows that LSD1 ablation in mammary tumor cells reduces NK cell-mediated anti-tumor immunity, leading to increased lung metastasis.

This study shows that estrogen receptor signaling in fallopian tube stromal cells maintains epithelial homeostasis by promoting proliferation and ciliated differentiation, but excessive estrogen shifts this niche toward inflammation and stemness, contributing to cancer initiation.

This study shows neuronal activity drives microglial reprogramming toward a pro-regenerative state during remyelination in MS models, altering gene expression related to oxidative phosphorylation and lipid metabolism.

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.