A new antibiotic from an uncultured bacterium binds to an immutable target
R. Shukla, A. J. Peoples, K. C. Ludwig, S. Maity, M. G. N. Derks, A. M. Krueger, S. de Benedetti, B. J. A. Vermeulen, R. V. Honorato, F. Grein, F. Lavore, A. M. J. J. Bonvin, U. Kubitscheck, E. Breukink, C. Achorn, , M. Weingarth
This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.
bioRxiv · May 15, 2023 · PreprintMicrobiology