Author

M. Weingarth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

R. Shukla· 3 shared A. M. J. J. Bonvin· 2 shared E. Breukink· 2 shared A. J. Peoples· 1 shared A. Javed· 1 shared A. L. Spoering· 1 shared A. M. Krueger· 1 shared A. Nitti· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

R. Shukla

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A new antibiotic from an uncultured bacterium binds to an immutable target

R. Shukla, A. J. Peoples, K. C. Ludwig, S. Maity, M. G. N. Derks, A. M. Krueger, S. de Benedetti, B. J. A. Vermeulen, R. V. Honorato, F. Grein, F. Lavore, A. M. J. J. Bonvin, U. Kubitscheck, E. Breukink, C. Achorn, , M. Weingarth

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

bioRxiv · May 15, 2023 · PreprintMicrobiology

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

F. van der Krift, D. W. Zijlmans, R. Shukla, A. Javed, P. I. Koukos, L. L. E. Schwarz, E. P. M. Timmermans-Sprang, P. E. M. Maas, D. Gahtory, M. van den Nieuwboer, J. A. Mol, G. J. Strous, A. M. J. J. Bonvin, E. J. A. Veldhuizen, M. van der Stelt, , M. M. Maurice

This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.

bioRxiv · Feb 26, 2023Biochemistry

Brevibacillin 2V, a novel antimicrobial lipopeptide with an exceptional low hemolytic activity

X. Zhao, X. Wang, R. Shukla, R. Kumar, M. Weingarth, E. Breukink, O. P. Kuipers

This study identifies and characterizes brevibacillin 2V, a novel antimicrobial lipopeptide with low hemolytic activity against eukaryotic cells, showing promise for antibiotic development.

bioRxiv · Apr 11, 2021Microbiology