S. Maity

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors

The paper improves the synthesis of C15AlkOPP and uses it to label and analyze prenylated proteins in motor neurons, astrocytes, and their stem cell progenitors, identifying 54, 50, and 84 prenylated proteins respectively.

Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironment

This study identifies obesity-induced changes in PDGFRα-expressing adipocyte progenitors that promote a cancer-susceptible mammary microenvironment through EGFR-mediated pathways.

Optimizing Phosphopeptide Structures That Target 14-3-3ϵ in Cutaneous Squamous Cell Carcinoma

This paper optimizes a phosphopeptide inhibitor of the 14-3-3ϵ-CDC25A interaction in cutaneous squamous cell carcinoma, achieving nanomolar affinity through peptide shortening and amino acid modification.

Melatonin induces endoreduplication through oxidative DNA-damage triggering lateral root formation in onions

This paper shows melatonin induces endoreduplication via oxidative DNA-damage, promoting lateral root formation in onions through ROS and cytokinin-dependent mechanisms.

A new antibiotic from an uncultured bacterium binds to an immutable target

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

Lateral membrane organization as target of an antimicrobial peptidomimetic compound

This study identifies how the antimicrobial peptide AMC-109 disrupts Staphylococcus aureus membrane organization, leading to loss of methicillin resistance.

Complex changes in serum protein levels in COVID-19 convalescents

This study identifies changes in serum protein levels in COVID-19 convalescents compared to healthy controls, revealing both similarities and differences with acute phase changes.

Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields

The paper introduces TiGGER, a time-resolved EPR method at high magnetic fields, to study protein mechanical dynamics, finding that light activation causes rapid separation and slow relaxation in AsLOV2.

Therapeutic potential of rWnt5A in curbing Leishmania donovani infection

This study shows that rWnt5A reduces L. donovani infection in macrophages and mice by increasing ROS and IFN-γ/IL-10 ratio, and improving immune cell function and splenic organization.

Proteomic signatures of the serological response to flu vaccination in a large human cohort study

The paper identifies proteomic signatures associated with seroconversion after flu vaccination in a human cohort, revealing links between protein levels and immune response factors.

Wnt5A Signaling Regulates Gut Bacterial Survival and T cell Homeostasis

This study shows that Wnt5A signaling promotes survival of gut commensals and affects T cell balance, highlighting its role in maintaining gut bacterial diversity and immune homeostasis.

Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation

This paper identifies a small-molecule inhibitor that targets TEAD palmitoylation, disrupting YAP-TEAD interaction and inhibiting cancer cell proliferation and migration.

Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

In vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer's disease reveals increased prenylation of a key set of proteins

The paper uses prenylomic analysis in AD mice to identify 36 prenylated proteins, with 15 showing increased levels, suggesting potential therapeutic targets.

Unfolding and identification of membrane proteins in situ

This study develops a pipeline using single-molecule force spectroscopy to analyze membrane proteins in situ, combining force-distance curves with mass spectrometry for identification and structural insights.

Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis

This study shows that Wnt5A signaling reduces susceptibility to visceral leishmaniasis by limiting infection progression and preserving immune cell function in mice.

Bio-Physical Modeling of Galvanic Human Body Communication in Electro-Quasistatic Regime

This paper develops a detailed lumped element model for Galvanic Human Body Communication (HBC) to analyze channel loss factors like tissue properties, electrode configuration, and return path capacitance.

Human ESCRT-III Polymers Assemble on Positively Curved Membranes and Induce Helical Membrane Tube Formation

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.

The ESCRT-III Isoforms CHMP2A And CHMP2B Display Different Effects On Membranes Upon Polymerization

This study compares the membrane interactions of CHMP2A and CHMP2B, finding they have distinct lipid binding preferences and mechanical effects on membranes.

Liquid-Liquid Phase Separation is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

This study shows that liquid-liquid phase separation of tau, an intrinsically disordered protein, is driven by conformational unwinding, solvation, and torsional fluctuations.