Author

C. Aitken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. L. Schulz· 2 shared C. B. Howard· 2 shared D. Roche Recinos· 2 shared L. F. Zacchi· 2 shared V. Sandford· 2 shared Y. Y. Lee· 2 shared B. F. Tan· 1 shared C. Espejo-Serrano· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

B. L. Schulz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription

C. Espejo-Serrano, C. Aitken, B. F. Tan, D. G. May, R. J. Chrisopulos, K. J. Roux, S. G. Mackintosh, J. Gribnau, F. Bustos, C. Gontan, G. M. Findlay

This study identifies how RNF12/RLIM E3 ubiquitin ligase targets specific genomic regions to regulate gene expression through chromatin interactions and autoinhibitory mechanisms.

bioRxiv · Jun 14, 2023 · PreprintCell Biology

Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product

L. F. Zacchi, D. Roche Recinos, C. L. Pegg, T. K. Phung, M. Napoli, C. Aitken, V. Sandford, S. M. Mahler, Y. Y. Lee, B. L. Schulz, C. B. Howard

The paper uses DIA-MS proteomics to predict rFIX yield and quality by analyzing bioreactor supernatant, identifying PTMs and their impact on purification and function.

bioRxiv · Jun 3, 2020Biochemistry

S-Trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants

L. F. Zacchi, D. Roche Recinos, E. Otte, C. Aitken, T. Hunt, V. Sandford, Y. Y. Lee, B. L. Schulz, C. B. Howard

This study compares sample preparation methods to remove polymeric surfactants from bioreactor supernatants, finding S-Trap provides the best clean-up and data quality.

bioRxiv · Feb 17, 2020Biochemistry