B. L. Schulz

Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes

This study identifies trace-level cytokines in PASC patients linked to cardiovascular symptoms and shows their impact on cardiomyocyte function using nanotechnology detection.

Capturing and Characterising Wild Yeast for Beer Brewing

The paper develops a pipeline to collect, characterize, and scale wild yeast for beer brewing, identifying interventions to overcome industrial fermentation challenges.

Electron-Activated Dissociation and Collision-Induced Dissociation Glycopeptide Fragmentation for Improved Glycoproteomics

This study compares fragmentation methods for glycopeptide analysis, finding CID identifies more glycopeptides while EAD improves site localization, and EAciD combines both benefits.

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

Proteomics and metabolomics reveal an abundant α-glucosidase drives sorghum fermentability for beer brewing.

The paper uses proteomics and metabolomics to analyze sorghum brewing, finding that an abundant α-glucosidase drives fermentability despite lower β-amylase levels.

Fine-tuning the Spike: Role of the nature and topology of the glycan shield in the structure and dynamics of SARS-CoV-2 S

This study uses molecular dynamics simulations to show how specific glycosylation sites on SARS-CoV-2 spike protein affect RBD stability and infectivity.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

N-glycosylation on Oryza Sativa Root Germin-like Protein 1 is conserved but not required for stability or activity

This study shows that N-glycosylation on OsRGLP1 is conserved but not required for stability or activity, and describes a method for its efficient production in E. coli.

The post-translational modification landscape of commercial beers

This study analyzes the post-translational modification landscape of 23 commercial Australian beers using DIA/SWATH-MS, revealing high diversity in PTMs and brewery-specific glyco/proteome profiles.

Benchtop micro-mashing: high-throughput, robust, experimental beer brewing

This paper introduces a micro-scale brewing method that enables high-throughput, replicable mashing for beer brewing, showing consistent proteomic and fermentable profiles across scales.

Quantitative data independent acquisition glycoproteomics of sparkling wine

This study quantitatively analyzes glycoproteomics in sparkling wines to assess aging and yeast strain effects on glycosylation profiles.

Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product

The paper uses DIA-MS proteomics to predict rFIX yield and quality by analyzing bioreactor supernatant, identifying PTMs and their impact on purification and function.

Proteomics reveals commitment to germination in barley seeds is marked by loss of stress response proteins and mobilisation of nutrient reservoirs

This study uses proteomics to show that barley seed germination involves loss of stress proteins and mobilization of nutrient stores, with differences in dormant seeds.

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

Identification of novel glycosylation events on human serum-derived Factor IX

The paper identifies two novel glycosylation sites on human Factor IX, including an O-linked site at serine 141 and an N-linked site at asparagine 258, contributing to structural characterization for therapeutic development.

Glycopeptide variable window SWATH for improved Data Independent Acquisition glycoprotein analysis

The paper improves DIA-MS glycoproteomics by using variable width windows optimized for glycopeptides, enhancing specificity and performance in glycopeptide analysis.

S-Trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants

This study compares sample preparation methods to remove polymeric surfactants from bioreactor supernatants, finding S-Trap provides the best clean-up and data quality.

Glycoproteomic measurement of site-specific polysialylation

This paper develops a high-throughput glycoproteomics method to measure site-specific polysialylation using LC-ESI-MS/MS after mild acid hydrolysis and desialylation.

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation

This study identifies RHBDL4 as a regulator of the oligosaccharyltransferase complex through ERAD-mediated degradation, revealing a novel link between ERAD and glycosylation regulation.

Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops

The paper identifies structural elements in plant purple acid phosphatases that influence substrate specificity, offering insights for improving phosphorus acquisition in crops.

Phase variable glycosylation in non-typeable Haemophilus influenzae

This study investigates phase variable glycosylation of HMW-A adhesins in NTHi, showing that cytoplasmic retention and glycosyltransferase expression affect glycosylation efficiency and site-specific variability.

The intrinsic and regulated proteomes of barley seeds in response to fungal infection

This study quantifies changes in barley seed proteomes under fungal infection using SWATH-MS, finding minimal and variable effects on seed proteins.

Post-translational modifications drive protein stability to control the dynamic beer brewing proteome

The paper examines how temperature and time affect protein stability and abundance during beer mashing, showing that structural and sequence features influence protein retention.

Proteomics reveals profound metabolic changes in the alcohol use disorder brain

The paper uses proteomics to identify metabolic changes in the brains of individuals with alcohol use disorder, revealing a shift toward acetate utilization.

Process proteomics of beer reveals a dynamic proteome with extensive modifications

This study uses mass spectrometry proteomics to analyze the dynamic proteome of beer production, identifying significant changes in protein abundance and modifications across process steps.