The landscape of somatic mutation in normal colorectal epithelial cells
H. Lee-Six, P. Ellis, R. J. Osborne, M. A. Sanders, L. Moore, N. Georgakopoulos, F. Torrente, A. Noorani, M. Goddard, P. Robinson, T. H. H. Coorens, L. O'Neill, C. Alder, J. Wang, R. C. Fitzgerald, , M. R. Stratton
This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.
bioRxiv · Sep 13, 2018Cancer Biology