L. Moore

Spatial genomics maps the structure, character and evolution of cancer clones

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

Effects of ploidy and salmonid alphavirus infection on the skin and gill microbiome of Atlantic salmon (Salmo salar)

This study compares the skin and gill microbiome of diploid and triploid Atlantic salmon, finding ploidy affects gill microbiome diversity and susceptibility to pathogens.

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

This study reconstructs the phylogeny of myeloproliferative neoplasms using whole-genome sequencing, revealing early mutation acquisition and lifelong clonal evolution leading to cancer.

CD38 contributes to human natural killer cell responses through a role in immune synapse formation

This study identifies CD38 as a key receptor in human NK cells that facilitates immune synapse formation, enhancing antiviral and antitumor responses.

The mutational landscape of normal human endometrial epithelium

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

The landscape of somatic mutation in normal colorectal epithelial cells

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.

Copy-number signatures and mutational processes in ovarian carcinoma

This study identifies copy-number signatures in ovarian cancer and links them to mutational processes, showing that most cases involve multiple processes, suggesting therapeutic challenges.