J. Wang

Tamoxifen and Doxorubicin Synergistically Target Estrogen Receptor beta-Mutant p53-p73 Axis, a Therapeutically Actionable Vulnerability in Triple Negative Breast Cancer

This paper shows that Tamoxifen and Doxorubicin together target the ER beta-mutant p53-p73 axis in TNBC, enhancing cell death through apoptosis and ferroptosis.

EBNA1 INHIBITORS REVEAL CDC7 AND POU2F1 AS DIRECT FUNCTIONAL TARGETS IN EBV EPITHELIAL CANCERS

This study identifies CDC7 and POU2F1 as direct targets of EBNA1 in EBV+ epithelial cancers using VK1727 inhibition, revealing new therapeutic strategies.

Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors

The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.

Characterizing cellular subpopulations critical to treatment response in autoimmune diseases

The paper identifies treatment response-associated cell subpopulations in autoimmune diseases by integrating single-cell and bulk data from IBD and PsO patients, revealing key pathways and cell types involved in response or non-response.

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Why is there so much variability in crop multi-model studies?

The paper investigates variability in crop model studies and finds parameter uncertainty contributes more than twice as much as structural uncertainty to total variability.

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

A drop dispenser for simplifying on-farm detection of foodborne pathogens

The paper develops a drop dispenser for on-farm detection of foodborne pathogens using LAMP, achieving performance comparable to commercial pipettors at a low cost.

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

Confinement in fibrous environments positions and orients mitotic spindles

This study investigates how ECM-confinement affects mitotic spindle positioning and orientation through mechanical interactions and RF patterning.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

In vivo evaluation of thermally drawn biodegradable optical fibers as brain neural interfaces

This study evaluates biodegradable PDLLA optical fibers as neural interfaces in mice, showing degradation and efficient SW-NIR light transmission with potential for optogenetics and therapy.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

The Molecular Architecture of the Nuclear Basket

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

A Collaborative DNA Barcode Library for the Diptera of Churchill, Canada: Exploration of Biodiversity and Biogeography

The paper presents a DNA barcode library for Diptera in Churchill, Canada, revealing biodiversity patterns and molecular evolution insights.

NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

Kilohertz volumetric imaging of in-vivo dynamics using squeezed light field microscopy

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

3D live imaging and phenotyping of the subcellular cytotoxicity in cancer immunotherapy using event-triggered Bessel oblique plane microscopy

This study uses EBOPM to analyze subcellular events in CAR-T cells during immunotherapy, identifying key parameters correlated with cytotoxic function.

Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradation

This study uses lipid nanoparticles to deliver peptide-based degraders, enabling targeted protein degradation in cancer cells and demonstrating reduced target levels in mice.