Cancer BiologybioRxiv
The landscape of somatic mutation in normal colorectal epithelial cells
H. Lee-Six, P. Ellis, R. J. Osborne…·M. R. Stratton
This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.
DOI 10.1038/s41586-019-1672-7