PhysiologybioRxivPreprint
Hepatocyte serine palmitoyl transferase 2 deficiency promotes liver C16:0-ceramide accumulation through sphingomyelin hydrolysis and leads to liver damage and dysfunction in mice
J. Lallement, I. Raho, G. Merlen…·C. Cruciani-Guglielmacci
This study shows that Sptlc2 deficiency in hepatocytes increases liver ceramide levels via sphingomyelin hydrolysis, leading to liver damage, dysfunction, and metabolic changes in mice.
DOI 10.1101/2021.09.16.460588