Author

I. Doignon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

D. Rainteau· 2 shared G. Merlen· 2 shared T. Tordjmann· 2 shared A. ABDELRAFEE· 1 shared C. Amouyal· 1 shared C. Cruciani-Guglielmacci· 1 shared C. Magnan· 1 shared C. ULLMER· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

D. Rainteau

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Author profile →

2 papers

Recent·Most cited

Hepatocyte serine palmitoyl transferase 2 deficiency promotes liver C16:0-ceramide accumulation through sphingomyelin hydrolysis and leads to liver damage and dysfunction in mice

J. Lallement, I. Raho, G. Merlen, D. Rainteau, M. Croyal, M. Schiffano, N. Kassis, I. Doignon, M. Soty, M. Krempf, C. Amouyal, H. Le Stunff, C. Magnan, T. Tordjmann, C. Cruciani-Guglielmacci

This study shows that Sptlc2 deficiency in hepatocytes increases liver ceramide levels via sphingomyelin hydrolysis, leading to liver damage, dysfunction, and metabolic changes in mice.

bioRxiv · Sep 16, 2021 · PreprintPhysiology

Bile Acid pool composition and Gallbladder function are controlled by TGR5 to protect the liver against Bile Acid overload

V. BIDAULT-JOURDAINNE, G. MERLEN, M. GLENISSON, I. DOIGNON, I. GARCIN, N. PEAN, R. BOISGARD, J. URSIC-BEDOYA, M. SERINO, C. ULLMER, L. HUMBERT, A. ABDELRAFEE, E. VIBERT, J.-C. DUCLOS-VALLEE, D. RAINTEAU, T. TORDJMANN

This study shows that TGR5 regulates bile acid pool composition and gallbladder function to protect the liver from bile acid overload in mice and humans.

bioRxiv · Feb 18, 2020 · PreprintPhysiology