Author

C. Aplin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

R. A. Cerione· 2 shared S. K. Milano· 2 shared D. Ogunribido· 1 shared K. A. Zielinski· 1 shared L. Pollack· 1 shared S. Feng· 1 shared S. Pabit· 1 shared T.-T. T. Nguyen· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersBiophysics

R. A. Cerione

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2 papers

Recent·Most cited

Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death

C. Aplin, K. A. Zielinski, S. Pabit, D. Ogunribido, W. P. Katt, L. Pollack, R. A. Cerione, S. K. Milano

This paper investigates the conformational states of TG2 and shows how an inhibitor stabilizes an open conformation that is cytotoxic to cancer cells.

bioRxiv · Feb 4, 2024 · PreprintBiophysics

Filament formation drives catalysis by glutaminase enzymes important in cancer progression

S. Feng, C. Aplin, T.-T. T. Nguyen, S. K. Milano, R. A. Cerione

This study shows that filament formation by glutaminase enzymes GAC and GLS2 is directly linked to their catalytic activity and presents cryo-EM structures revealing the conformational changes essential for glutaminolysis in cancer.

bioRxiv · Feb 16, 2023 · PreprintBiophysics