BiophysicsbioRxivPreprint
Filament formation drives catalysis by glutaminase enzymes important in cancer progression
S. Feng, C. Aplin, T.-T. T. Nguyen…·R. A. Cerione
This study shows that filament formation by glutaminase enzymes GAC and GLS2 is directly linked to their catalytic activity and presents cryo-EM structures revealing the conformational changes essential for glutaminolysis in cancer.
DOI 10.1101/2023.02.16.528860