Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α
S. Moulin, B. Blachot-Minassian, A. Kneppers, A. Thomas, S. Paradis, L. Bultot, C. Arnaud, J.-L. Pepin, L. Bertrand, R. Mounier, E. Belaidi
This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.
bioRxiv · Jan 11, 2024Physiology