Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP
E. Cohen, A. Zhu, C. Auffray, M. Bomsel, Y. Ganor
This study shows that TRPV1 activation in Langerhans cells increases CGRP secretion, which inhibits HIV-1 trans-infection, suggesting TRPV1 agonists could be used as topical microbicides.
bioRxiv · Mar 8, 2021 · PreprintMicrobiology