Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection
P. Aguilar Calvo, A. Malik, D. Sandoval, C. Barback, C. Orru, H. Standke, O. Thomas, C. Dwyer, D. Pizzo, J. Bapat, K. Soldau, R. Ogawa, M. Riley, P. Nilsson, a. kraus, , C. J. Sigurdson
This study shows that reducing HS sulfation in neurons slows prion disease progression by enhancing prion protein clearance and reducing plaque formation.
bioRxiv · Jun 19, 2023 · PreprintPathology