A. Malik

RelQ-mediated alarmone signaling regulates growth, sporulation, and stress-induced biofilm formation in Clostridioides difficile

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

This study shows that reducing HS sulfation in neurons slows prion disease progression by enhancing prion protein clearance and reducing plaque formation.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

Overexpression of Interleukin-8 and Interleukin-13 as potent immune markers associated with survival and dietary habits in esophageal squamous cell carcinoma.

The paper evaluates the expression of IL8, IL12, and IL13 in ESCC patients and links their levels to survival, clinicopathological factors, and dietary habits.

Scavenger receptor B1 facilitates the endocytosis of Escherichia coli via TLR4 signaling in mammary gland infection

This study shows SCARB1 facilitates E. coli endocytosis in goat mammary epithelial cells via TLR4 signaling during infection.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

This study uses in vivo CRISPR screens to identify USP15 and SCAF1 as novel tumor suppressors in pancreatic cancer, with potential therapeutic implications.

Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease

The paper measures de novo mutation rates at single-mutation resolution in a human HBB gene region, finding higher rates in Africans and significant variation in specific mutations.

Cellular pathways during spawning induction in the starlet sea anemone Nematostella vectensis

The paper analyzes transcriptional changes during spawning induction in Nematostella vectensis, revealing upregulated signal perception and cytoskeleton processes and downregulated fatty acid metabolism and housekeeping functions.

Finding Pathogenic nsSNP's and their structural effect on COPS2 using Molecular Dynamic Approach

The paper evaluates 90 nsSNPs in COPS2 using computational tools and molecular dynamics to identify pathogenic mutations affecting protein structure and function.

Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

Interfacial Water Molecules Make RBD of SPIKE Protein and Human ACE2 to Stick Together

The paper analyzes the protein-protein interactions between SARS-CoV-2 spike RBD and hACE2, finding that interfacial water molecules stabilize their binding.

Optimization of skeletal protein preparation for LC-MS/MS sequencing yields additional coral skeletal proteins in Stylophora pistillata

This study compares four protein purification methods from coral skeletons, identifying 60 proteins, 44 new to stony coral proteomes, and suggests non-traditional secretion pathways for skeletal protein transport.

A tentacle for every occasion: comparing the hunting tentacles and sweeper tentacles, used for territorial competition, in the coral Galaxea fascicularis

This study compares the histology, gene expression, and toxin activity of two tentacle types in the coral Galaxea fascicularis, revealing distinct venom apparatuses for prey capture and territorial aggression.

The role of land use types and water chemical properties in structuring the microbiomes of a connected lakes system

The paper examines how land use and water chemistry influence microbiomes in a connected lakes system, finding that land use within drainage basins affects water quality and microbial structure, while direct land use around lakes has minimal impact.

Possible co-option of a VEGF-driven tubulogenesis program for biomineralization in echinoderms

This study identifies parallels between VEGF-driven tubulogenesis in sea urchin spiculogenesis and vertebrate vascularization, suggesting a shared ancestral program co-opted for biomineralization.

Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

The paper investigates MATR3's role in neurotoxicity, finding that its RNA binding and localization affect neuronal survival and disease mechanisms.