ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157
D. Feuerbach, P. Schindler, C. Barske, S. Joller, E. Beng-Louka, K. A. Worringer, S. Kommineni, A. Kaykas, D. J. Ho, C. Ye, K. Welzenbach, G. Elain, L. Klein, I. Brzak, A. K. Mir, , U. Neumann
This study identifies ADAM17 as the primary sheddase for TREM2 ectodomain release and determines the cleavage site at histidine 157.
bioRxiv · May 3, 2017Cell Biology