U. Neumann

The barley MLA13-AVRA13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors

The paper determines the cryo-EM structure of the MLA13-AVRA13-1 heterodimer and shows how a single amino acid substitution in MLA7 expands effector recognition.

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

Amphicarpic development in the emerging model organism Cardamine chenopodiifolia

This paper establishes Cardamine chenopodiifolia as a model system for studying amphicarpy, identifying differentially expressed genes and developmental differences between above- and below-ground fruits.

Apoplastic barrier establishment in roots and nodules of Lotus japonicus is essential for root-shoot signaling and N-fixation

This study identifies the role of apoplastic barriers in Lotus japonicus roots and nodules, showing their necessity for nitrogen fixation and root-shoot signaling.

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

Root barrier surveillance mechanisms convey soil nitrogen status to shoots

This study rewires root barrier formation to investigate the role of the Schengen pathway in conveying soil nitrogen status to shoots and its impact on root microbiome and plant growth.

A high confidence Physcomitrium patens plasmodesmata proteome by iterative scoring and validation reveals diversification of cell wall proteins during evolution

The paper identifies a high-confidence plasmodesmata proteome in Physcomitrium patens using iterative scoring and validation, revealing evolutionary diversification of cell wall proteins.

A conserved enzyme of smut fungi facilitates cell-to-cell movement in the plant bundle sheath

The paper identifies Erc1 as a conserved enzyme in smut fungi that enables cell-to-cell movement in plant bundle sheath cells, contributing to virulence across different host species.

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

The Ustilago hordei-barley interaction is a versatile system to characterize fungal effectors

This study presents Ustilago hordei as a model system for characterizing fungal effectors using genetic tools and microscopy analysis.

Flowering behaviour in Arabis alpina ensures the maintenance of a perennating dormant bud bank

This study shows that floral development during vernalization in Arabis alpina shapes the dormant bud zone by promoting synchronized growth and auxin levels after warming, while apical dominance and temperature regulate dormancy.

ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157

This study identifies ADAM17 as the primary sheddase for TREM2 ectodomain release and determines the cleavage site at histidine 157.