Author

L. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Plant Biology· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. Topp· 2 shared L. Urbach· 2 shared M. Li· 2 shared M. Tu· 2 shared U. Kishore· 2 shared V. Coneva· 2 shared V. Ellenrieder· 2 shared A. Atta-Boateng· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPlant Biology

C. Topp

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

L. Klein, M. Tu, N. Krebs, L. Urbach, D. G. Grimm, M. U. Latif, F. Penz, N. Chan, K. Aliar, F. Vyas, U. Kishore, E. Hessmann, A. Trumpp, E. Espinet, A. Papantonis, , S. K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

U. Kishore, P. Varghese, A. Mangogna, L. Klein, M. Tu, L. Urbach, M. Qiu, R. Nicolle, V. Murugaiah, N. Beirag, S. Roth, D. Pedersen, R. Sim, V. Ellenrieder, G. R. Andersen, , S. Singh

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

bioRxiv · Oct 28, 2023 · PreprintImmunology

Inactivation mechanisms of Influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS.

S. C. David, O. Vadas, I. Glas, A. Schaub, B. Luo, G. C. D'Angelo, J. Paz Montoya, N. Bluvshtein, W. Hugentobler, L. Klein, G. Motos, M. Pohl, K. Violaki, A. Nenes, U. Krieger, , T. Kohn

This study identifies how Influenza A virus inactivates under acidic aerosol conditions using HDX-MS, revealing HA conformational changes and M1 unfolding as key mechanisms.

bioRxiv · Nov 1, 2022Microbiology

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

L.-M. Jenster, K.-E. Lange, S. Normann, A. vom Hemdt, J. D. Wuerth, L. D. J. Schiffelers, Y. M. Tesfamariam, F. N. Gohr, L. Klein, I. H. Kaltheuner, D. J. Lapp, J. Mayer, J. Moecking, H. L. Ploegh, E. Latz, , F. I. Schmidt

This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.

bioRxiv · Jan 24, 2022Immunology

Persistent homology demarcates a leaf morphospace

M. Li, H. An, R. Angelovici, C. Bagaza, A. Batushansky, L. Clark, V. Coneva, M. Donoghue, E. Edwards, D. Fajardo, H. Fang, M. Frank, T. Gallaher, S. Gebken, T. Hill, , D. H. Chitwood

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.

bioRxiv · Jun 20, 2017Plant Biology

ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157

D. Feuerbach, P. Schindler, C. Barske, S. Joller, E. Beng-Louka, K. A. Worringer, S. Kommineni, A. Kaykas, D. J. Ho, C. Ye, K. Welzenbach, G. Elain, L. Klein, I. Brzak, A. K. Mir, , U. Neumann

This study identifies ADAM17 as the primary sheddase for TREM2 ectodomain release and determines the cleavage site at histidine 157.

bioRxiv · May 3, 2017Cell Biology

Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences

A. Bucksch, A. Atta-Boateng, A. F. Azihou, M. Balduzzi, D. Battogtokh, A. Baumgartner, B. Binder, S. Braybrook, C. Chang, V. Coneva, T. DeWitt, A. Fletcher, M. Gehan, D. Hernan Diaz Martinez, L. Hong, , D. Chitwood

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.

bioRxiv · Feb 8, 2017Plant Biology