Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model
S. Biradar, Y. Agarwal, A. Das, S. T. Shu, J. Samal, S. Ho, C. Beatty, I. Castronova, R. B. Mailliard, T. E. Smithgall, M. T. Bility
The paper shows that preventing Nef dimerization in HIV reduces viremia and immune dysregulation in a humanized mouse model.
bioRxiv · Jan 21, 2021 · PreprintImmunology