PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits
K. Saitoski, M. Ryaboshapkina, G. Hamza, A. F. Jarnuczak, C. Berthault, F. Carlotti, M. Armanet, K. Sengupta, C. Rye Underwood, S. Andersson, I. Guillas, W. Le Goff, R. Scharfmann
This study shows PCSK9 regulates surface proteins in pancreatic beta cells via intra- and extracellular mechanisms, affecting insulin secretion and immune-related proteins.
bioRxiv · Sep 28, 2021 · PreprintCell Biology