R. Scharfmann

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits

This study shows PCSK9 regulates surface proteins in pancreatic beta cells via intra- and extracellular mechanisms, affecting insulin secretion and immune-related proteins.

Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

This study compares human and mouse enteroendocrine cells using transcriptomic and peptidomic profiling to assess mouse as a model for human enteroendocrine function.