K. Sengupta

A "through-DNA" mechanism for metal uptake-vs.-efflux regulation

The paper reveals a through-DNA mechanism where ZntR influences Zur's DNA binding kinetics, enabling coordinated metal uptake and efflux regulation in E. coli.

Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer

The paper investigates how chromatin organization and gene regulation change with evolutionary age during differentiation and cancer, identifying shifts in chromatin topology and gene interactions.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Talin and kindlin cooperate to control the density of integrin clusters.

This study shows that talin and kindlin work together to control integrin cluster density, with kindlin enhancing talin and integrin density and facilitating cluster segregation by actomyosin.

Probing mechanical interaction of immune receptors and cytoskeleton by membrane nanotube extraction

This study uses mechanical extraction and modeling to investigate the mechanical link between immune receptors and the cytoskeleton, revealing that TCR-complex and open LFA1 form such links.

Elevated levels of lamin A promote HR and NHEJ-mediated repair mechanisms in etoposide-treated ovarian cancer cells

The paper shows that elevated lamin A in ovarian cancer cells enhances DNA repair via HR and NHEJ mechanisms in response to etoposide treatment.

Spatio-temporal Force Patterns Reveal a Mechanical Set Point in Early T Cell Activation

This study uses traction force microscopy to analyze early T cell force generation and identifies distinct mechanical response patterns in human T cells.

Microdynamics of lamin A Ig-fold domain regulates higher order assembly of the protein

This study investigates how mutations in the lamin A Ig-fold domain affect its dynamics and assembly into the nuclear lamina using live cell imaging, FCS, and MD simulations.

PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits

This study shows PCSK9 regulates surface proteins in pancreatic beta cells via intra- and extracellular mechanisms, affecting insulin secretion and immune-related proteins.

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies

This study uses active microrheology with optical tweezers to measure viscoelastic changes in lamin A mutants, linking structural alterations to disease mechanisms in laminopathies.

Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL): A novel architecture for accurate diagnosis/prognosis of Ovarian Cancer

This paper introduces a novel deep hybrid learning architecture, NUMODRIL, for classifying ovarian cancer tissues based on nuclear morphology and lamin protein distribution, achieving high accuracy and efficiency.

Principles of organelle membranebridging established using cytosolictether mimics

The paper establishes principles of organelle membrane bridging using DNA tether mimics in GUV and SLB systems, showing adhesion driven by entropic effects rather than enthalpic binding.

Coexistence of long and short DNA constructs within adhesion plaques

The paper studies DNA bridge organization in adhesion domains using a model system, finding coexisting long and short DNA constructs despite length differences.

Alteration of epigenetic landscape by lamin A mutations: Hallmark of Dilated Cardiomyopathy

This study examines how lamin A mutations alter the epigenetic landscape in C2C12 cells, identifying specific histone modifications and RNA polymerase II changes associated with dilated cardiomyopathy.

Nuclear deformation and anchorage defect induced by DCM mutants in lamin A

This study examines how DCM-causing lamin A mutants affect nuclear deformation and anchorage under mechanical stress.

Biphasic mechanosensitivity of TCR mediated adhesion of T lymphocytes

The paper shows T cells exhibit biphasic adhesion responses to environmental stiffness via TCR, with maximal adhesion on optimally stiff surfaces, and identifies key molecular parameters determining this behavior.