S. Andersson

Ancient amino acid sets enable stable protein folds

The paper designs ancient proteins using a limited amino acid set and shows they are stable and mutation-resilient.

Cell Types or Cell States? An Investigation of Adrenergic and Mesenchymal Cell Phenotypes in Neuroblastoma

The paper investigates whether adrenergic and mesenchymal phenotypes in neuroblastoma represent distinct cell types or dynamic cell states through theoretical modeling and hypothesis testing.

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

Golgi organization is a determinant of stem cell function in the small intestine

This study shows that Lgr5+ stem cells in the small intestine adjust their Golgi apparatus orientation to enhance niche signal reception and tissue regeneration, which is impaired with age.

MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma

The paper identifies MOXD1 as a tumor-suppressor gene in neuroblastoma by analyzing bulk and single-cell RNA sequencing data and validating its role in organ homeostasis across multiple species.

PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits

This study shows PCSK9 regulates surface proteins in pancreatic beta cells via intra- and extracellular mechanisms, affecting insulin secretion and immune-related proteins.

Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immuno-staining

The paper optimizes cell fixation and immuno-staining to quantitatively retain and visualize exogenously delivered and endogenous nucleic acids in sub-cellular compartments.

Nuclear envelope budding is a response to cellular stress

The paper shows nuclear envelope budding increases in response to cellular stress in yeast, suggesting a role in protein quality control.

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

The paper visualizes mRNA escape from endosomal recycling tubules using super-resolution microscopy and identifies parameters affecting endosomal escape and cytotoxicity in human cells.

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity and an important role for transcriptional and translational control

The paper identifies molecular factors involved in arsenite-induced protein aggregation and toxicity using a genome-wide imaging screen in yeast, showing the importance of transcriptional and translational control in proteostasis.

Contrasting patterns of genome-level diversity across distinct co-occurring bacterial populations

The paper examines genetic and ecological differentiation in freshwater bacterial populations using single-cell genomes and metagenomic data, finding ecologically distinct populations within some lineages but not others.