Author

M. Ranaghan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Ianari· 2 shared A. Skepner· 2 shared D. C. McKinney· 2 shared D. Porter· 2 shared K. M. Mulvaney· 2 shared W. R. Sellers· 2 shared A. J. Nelson· 1 shared B. Bajrami· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

A. Ianari

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Author profile →

2 papers

Recent·Most cited

Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction

D. C. McKinney, B. J. McMillan, M. Ranaghan, J. A. Moroco, M. Brousseau, Z. Mullin-Bernstein, M. O'Keefe, P. McCarren, M. F. Mesleh, K. M. Mulvaney, R. Singh, B. Bajrami, A. Skepner, D. E. Timm, D. Porter, , A. Ianari

The paper identifies a first-in-class inhibitor, BRD0639, that targets the PRMT5-PBM interaction, disrupting SAP binding and reducing substrate methylation in cancer cells.

bioRxiv · Feb 3, 2021 · PreprintCancer Biology

Molecular basis for substrate recruitment to the PRMT5 methylosome

K. M. Mulvaney, C. Blomquist, N. Acharya, R. Li, M. OKeefe, M. Ranaghan, M. Stokes, A. J. Nelson, S. S. Jain, J. Columbus, F. K. Bozal, A. Skepner, D. Raymond, D. C. McKinney, Y. Freyzon, , W. R. Sellers

The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.

bioRxiv · Aug 22, 2020Cancer Biology