Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis
S. Schulz, C. Schall, T. Stehle, C. Breitmeyer, S. Krysenko, A. Bera, W. Wohlleben
This paper improves FK-506 production in Streptomyces tsukubaensis by engineering precursor supply and enzyme activity, achieving a 100% yield increase over the wild type.
bioRxiv · Mar 16, 2022 · PreprintBioengineering