S. Schulz

The deletion of aldehyde:ferredoxin oxidoreductase-encoding genes in Clostridium ljungdahlii results in changes in the product spectrum with various carbon sources

This study deletes AOR genes in C. ljungdahlii and shows changes in ethanol and acetic acid production with different carbon sources.

Genomics of Neotropical biodiversity indicators: two butterfly radiations with rampant chromosomal rearrangements and hybridisation

This study examines two Neotropical butterfly radiations, revealing high rates of hybridization and chromosomal rearrangements as drivers of diversification.

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

Cellular and molecular characterization of peripheral glia in the lung and other organs

This study characterizes peripheral glia in the lung and other organs using scRNA-seq, identifying molecularly distinct populations and conserved gene expression across species.

Phylogeny not mimicry drives chemical variation in tropical aposematic butterflies

The paper examines chemical profiles of aposematic butterflies and finds that phylogenetic relationships, not mimicry, drive chemical variation among species.

Phosphorylation bar-coding of Free Fatty Acid receptor 2 is generated in a tissue-specific manner

The paper demonstrates tissue-specific phosphorylation patterns of FFA2 in response to the same agonist in different tissues using transgenic mice and phospho-specific antibodies.

A fast-slow trait continuum at the level of entire communities

The paper shows that slow and fast functional strategies manifest at the ecosystem level, driven by disturbance and resource availability in grassland communities.

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies

This paper demonstrates that phosphatase inhibitors are essential for preserving phosphorylated GPCR states during immunohistochemistry, enabling accurate visualization of drug-induced receptor activation in native tissues.

Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis

This paper improves FK-506 production in Streptomyces tsukubaensis by engineering precursor supply and enzyme activity, achieving a 100% yield increase over the wild type.

The Omicron variant is highly resistant against antibody-mediated neutralization - implications for control of the COVID-19 pandemic

This study shows the Omicron variant is highly resistant to antibody neutralization, reducing effectiveness of current therapies and vaccines.

Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data

This paper presents a data-driven workflow to design microbial strains using aggregated ALE mutational data, revealing gene-centric mutations that significantly alter cellular states.

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

Clustering of loci controlling species differences in male chemical bouquets of sympatric Heliconius butterflies

The paper investigates the genetic architecture of male pheromone compound production in Heliconius butterflies, finding significant QTL clustering on specific chromosomes.

A major locus controls a biologically active pheromone component in Heliconius melpomene

This study identifies a major genetic locus controlling octadecanal production in Heliconius melpomene, a biologically active pheromone component involved in mate choice.

Chemical signals act as the main reproductive barrier between sister and mimetic Heliconius butterflies

The paper identifies chemical signals as the primary reproductive barrier between two closely related, co-mimic Heliconius butterfly species.

Species specificity and intraspecific variation in the chemical profiles of Heliconius butterflies across a large geographic range

The paper examines chemical profile divergence in Heliconius butterflies, finding strong interspecific differences and some intraspecific variation, with implications for species recognition.

A novel terpene synthase produces an anti-aphrodisiac pheromone in the butterfly Heliconius melpomene

The paper identifies a novel terpene synthase in Heliconius melpomene that synthesizes (E)-β-ocimene, an anti-aphrodisiac pheromone, showing it evolved independently from plant and other insect TPSs.

Parameters and determinants of responses to selection in antibody libraries

The paper quantifies how scaffold evolutionary maturation affects antibody library response to selection, finding maturated scaffolds show lower response to arbitrary targets.

Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib Penetration into Liver Metastases of Gastrointestinal Stromal Tumors

The paper uses MSI to show imatinib does not penetrate GIST liver metastases, despite being present in healthy liver tissue, suggesting mutation-independent resistance.

Nocturnal scent in a 'bird-fig': a cue to attract bats as additional dispersers?

The study investigates how the bird-fig Ficus colubrinae attracts the bat Ectophylla alba at night despite its fruit traits typically appealing to birds, finding that scent is the main foraging cue for bats.

Male pheromone composition depends on larval but not adult diet in Heliconius melpomene

The study investigates how larval and adult diets affect pheromone composition in male Heliconius melpomene, finding no effect of adult diet but variation due to larval host plants.

Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity

This study evaluates cognitive dysfunction in Cyclin-D2 knockout mice, finding impaired executive function and working memory linked to hippocampal over-activity in a schizophrenia model.