Author

T. Stehle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Bioengineering· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:proteomics· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

A. Di Maio· 3 shared Y. Liu· 3 shared D. Alsteens· 2 shared L. M. Silva· 2 shared M. Koehler· 2 shared R. dos Santos Natividade· 2 shared T. Feizi· 2 shared T. S. Dermody· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

A. Di Maio

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Novel multifunctional glycan probes to elucidate specificities of diverse glycan recognition systems

J. Yu, A. C. Decout, A. Di Maio, W. Chai, T. Stehle, B. Turnbull, T. Feizi, Y. Liu

This paper develops novel glycan probes with a tri-functional linker for generating noncovalent and covalent arrays, revealing differences in glycan binding by various proteins on different array platforms.

bioRxiv · Jul 9, 2023 · PreprintBiochemistry

A novel and highly specific Forssman antigen-binding protein from sheep polyomavirus

N. H. Rustmeier, L. M. Silva, A. Di Maio, J. C. Müller, A. Herrmann, T. Feizi, Y. Liu, T. Stehle

This paper identifies the Forssman glycolipid as a receptor for sheep polyomavirus and reports the first viral protein specifically binding to this antigen.

bioRxiv · Apr 10, 2023 · PreprintBiochemistry

Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirus

M. Sorin, A. Di Maio, L. M. Silva, D. Ebert, C. Delannoy, N.-K. Nguyen, Y. Guerardel, W. Chai, F. Halary, K. Renaudin-Autain, Y. Liu, C. Bressollette-Bodin, T. Stehle, D. McILROY

This study analyzes natural VP1 mutations in BKPyV to show some variants can enter cells without sialic acid, suggesting an alternative receptor.

bioRxiv · Jul 13, 2022 · PreprintMicrobiology

Genetic diversity of Staphylococcus aureus wall teichoic acid glycosyltransferases affects immune recognition

S. M. Tamminga, S. L. Völpel, K. Schipper, T. Stehle, Y. Pannekoek, N. M. van Sorge

The paper analyzes the genetic diversity of three WTA glycosyltransferases in S. aureus and shows their impact on immune recognition through functional assays.

bioRxiv · May 25, 2022Microbiology

Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis

S. Schulz, C. Schall, T. Stehle, C. Breitmeyer, S. Krysenko, A. Bera, W. Wohlleben

This paper improves FK-506 production in Streptomyces tsukubaensis by engineering precursor supply and enzyme activity, achieving a 100% yield increase over the wild type.

bioRxiv · Mar 16, 2022 · PreprintBioengineering

Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)

J. R. Hemsath, M. Liaci, J. Rubin, B. Parrett, S.-C. Lu, T. Nguyen, M. Turner, C. Chen, V. S. Reddy, K. Cupelli, T. Stehle, K. Liszewski, J. Atkinson, M. A. Barry

This paper investigates the CD46 receptor utilization by Ad26 in vitro and in vivo, showing its role in infection and safety, but not all routes of administration.

Journal of Virology · Feb 9, 2022Peer-reviewedPharmacology & Toxicology

The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection

D. M. Sutherland, M. Strebl, M. Koehler, O. L. Welsh, X. Yu, L. Hu, R. dos Santos Natividade, J. J. Knowlton, G. M. Taylor, R. Moreno, P. Woerz, Z. L. Lonergan, P. Aravamudhan, C. Guzman-Cardozo, D. Alsteens, , T. S. Dermody

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

bioRxiv · Jul 23, 2021 · PreprintMicrobiology

Reovirus σ1 conformational flexibility modulates the efficiency of host cell attachment

J. R. Diller, S. R. Halloran, M. Koehler, R. dos Santos Natividade, D. Alsteens, T. Stehle, T. S. Dermody, K. M. Ogden

This study shows that conformational flexibility of reovirus σ1 protein affects host cell attachment efficiency by engineering cysteine mutations that alter σ1 structure.

Journal of Virology · Nov 9, 2020Peer-reviewedMicrobiology

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

T. R. Wagner, P. D. Kaiser, M. Gramlich, E. Ostertag, N. Ruetalo, D. Junker, J. Haering, B. Traenkle, M. Becker, A. Dulovic, H. Schweizer, S. Nueske, A. Scholz, A. Zeck, K. Schenke-Layland, , U. Rothbauer

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

bioRxiv · Sep 22, 2020 · PreprintImmunology