A. Bera

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

Small-molecule binding and sensing with a designed protein family

This paper designs a protein family that binds and senses small molecules using deep learning and physics-based methods, achieving nanomolar sensitivity for cortisol.

De novo designed ice-binding proteins from twist-constrained helices

This paper designs ice-binding proteins with controlled under-twisting of alpha-helices to enhance ice recrystallization inhibition.

Robust deep learning based protein sequence design using ProteinMPNN

A deep learning method for protein sequence design shows high performance in both simulations and experiments, applicable to various design challenges.

Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis

This paper improves FK-506 production in Streptomyces tsukubaensis by engineering precursor supply and enzyme activity, achieving a 100% yield increase over the wild type.

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration into human lung cells

This study shows cardiac medications like ouabain and digitoxin inhibit ACE2 binding to SARS-CoV-2 Spike and block virus entry into human lung cells.

Haploinsufficient tumour suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition

This study shows PRP4K is a haploinsufficient tumor suppressor whose levels are reduced during EMT, promoting invasion without full EMT in mammary cells.