Author

C. Castrillon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:clustering· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. C. Carroll· 3 shared M. Ma· 2 shared T. van den Broek· 2 shared A. G. Schmidt· 1 shared A. Perima· 1 shared A. Robbins· 1 shared A. Sokal· 1 shared A. Vandenberghe· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

M. C. Carroll

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4 papers

Recent·Most cited

Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells

D. Y.-D. Zhu, D. P. Maurer, C. Castrillon, Y. Deng, F. A. N. Mohamed, M. Ma, A. G. Schmidt, D. Lingwood, M. C. Carroll

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

bioRxiv · Jan 9, 2024 · PreprintImmunology

Invasion of spontaneous germinal centers by naive B cells is rapid and persistent

T. van den Broek, K. Oleinika, S. Rahmayanti, C. Castrillon, C. E. van der Poel, M. C. Carroll

The paper shows wild-type B cells rapidly and persistently invade autoreactive germinal centers, leading to clonal expansion and autoantibody production.

bioRxiv · May 30, 2023Immunology

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

C. Castrillon, L. Simoni, T. van den Broek, C. van der Poel, E. H. Akama-Garren, M. Ma, M. C. Carroll

The paper characterizes post-germinal center B cell subsets in a mouse model of autoimmunity, finding clonal redundancy across antibody secreting cells and memory B cells.

bioRxiv · Jun 21, 2022Immunology

Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells

P. Canales Herrerias, E. Crickx, M. Broketa, A. Sokal, G. Chenon, I. Azzaoui, A. Vandenberghe, A. Perima, B. Iannascoli, O. Richard-Le Goff, C. Castrillon, G. Mottet, D. Sterlin, A. Robbins, M. Michel, , P. Bruhns

This study identifies high-affinity autoreactive plasma cells in multiple organs of ITP patients, showing treatment resistance and suggesting therapy failure mechanisms.

bioRxiv · Jun 29, 2021 · PreprintImmunology