M. Ma

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Identification of a distinct cluster of GDF15high macrophages exhibiting anti-inflammatory activities

The paper identifies a distinct cluster of GDF15high macrophages with anti-inflammatory properties using single-cell RNA sequencing and functional assays.

Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

This study identifies NFAT5 as a direct sensor and effector of ionic stress in animal cells, showing it forms condensates to activate genes restoring ion balance.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

The effector recognition by synthetic sensor NLR receptors requires the concerted action of multiple interfaces within and outside the integrated domain

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

The paper characterizes post-germinal center B cell subsets in a mouse model of autoimmunity, finding clonal redundancy across antibody secreting cells and memory B cells.

Androgen Receptor is a Determinant of Melanoma Targeted Drug Resistance

This study shows that androgen receptor activity contributes to melanoma resistance to BRAF/MEK inhibitors and suggests targeting AR could improve treatment outcomes.

Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection

Apadenoson, an A2AR agonist, improves survival and reduces inflammation in K18hACE2 mice infected with SARS-CoV-2 when administered after infection.

In vitro phenotypic and transcriptomic variation in Neisseria musculi morphotypes correlate with colonization variability and persistence in vivo

This study compares in vitro and in vivo phenotypes of two Neisseria musculi morphotypes, showing differences in colonization patterns and persistence in mice.

The endoplasmic reticulum membrane protein complex (EMC) negatively regulates intestinal homeostasis through the Hippo signaling pathway

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

DNA methylation in transposable elements disrupts the connection between three-dimensional chromatin organization and gene expression upon rice genome duplication.

This study investigates how DNA methylation in transposable elements disrupts the link between 3D chromatin organization and gene expression in rice after genome duplication.

Unraveling a Bacterial Starvation Response Through the Direct Targets of a Starvation-Induced Transcriptional Activator

This study identifies Nla28 target genes in Myxococcus xanthus during starvation, revealing their roles in spore production and stress resistance.

On-tissue spatial proteomics integrating MALDI-MS imaging with shotgun proteomics reveals soy consumption-induced biomarkers in a fragile X syndrome mouse model

CAR-NK Cells Effectively Target the D614 and G614 SARS-CoV-2-infected Cells

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

Complete depletion of Arabidopsis linker histones impairs the correlations among chromatin compartmentalization, DNA methylation and gene expression

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

This study shows that androgen receptor signaling promotes melanoma cell growth and tumorigenesis, with AR inhibition reducing proliferation, enhancing DNA repair, and inducing immune responses.

Negative effects characterization and comparative transcriptomics elucidation on the lag phase of an industrial S. cerevisiae under the corn stover hydrolysate stress

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

Covalent Protein Painting Reveals Structural Changes in the Proteome in Alzheimer Disease

The paper introduces CPP, a method to quantify lysine accessibility in proteins, and finds altered lysine accessibility in Alzheimer's disease patients.

Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors

The paper develops a synthetic fluorescent biosensor to monitor MAPK activity dynamics in live cells, showing improved sensitivity and applicability across multiple cell types and conditions.

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.

Effects of topical PaiTeLing in nude mice implanted with human condyloma acuminatum tissue infected with HPV 6, 31, and 81: comparison with imiquimod and interferon-α-2b

This study compares the effects of PaiTeLing, imiquimod, and interferon-α-2b on HPV-infected tissue in nude mice, finding enhanced immune responses with imiquimod and PaiTeLing.

High-glucose Induces Retinal Pigment Epithelium Mitochondrial Pathways of Apoptosis and Inhibits Mitophagy by Regulating ROS/PINK1/Parkin Signal Pathway

This study shows high-glucose induces RPE apoptosis and inhibits mitophagy by disrupting the ROS/PINK1/Parkin pathway.